The Molecular Biology of Axon Guidance -- Tessier-Lavigne and Goodman 274 (5290): 1123 -- Science
نویسندگان
چکیده
Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is accumulating that these mechanisms act simultaneously and in a coordinated manner to direct pathfinding and that they are mediated by mechanistically and evolutionarily conserved ligand-receptor systems.
منابع مشابه
The molecular biology of axon guidance.
Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is accumulating that these mechanisms act sim...
متن کاملMidline Guidance Defects in Slit Triple Mutants
Neuron Immediate Early Publication Copyright ©2004 by Cell Press Published Online April 15, 2004 DOI: 10.1016/S0896-627304001795 Conserved Roles for Slit and Robo Proteins in Midline Commissural Axon Guidance Hua Long, Christelle Sabatier, Le Ma, Andrew Plump, Wenlin Yuan, David M. Ornitz, Atsushi Tamada, Fujio Murakami, Corey S. Goodman, and Marc Tessier-Lavigne* Howard Hughes Medical Institut...
متن کاملGuidance of developing axons by diffusible chemoattractants.
service Email alerting click here the box at the top right corner of the article or Receive free email alerts when new articles cite this article-sign up in
متن کاملNovel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance.
During embryonic development, morphogens act as graded positional cues to dictate cell fate specification and tissue patterning. Recent findings indicate that morphogen gradients also serve to guide axonal pathfinding during development of the nervous system. These findings challenge our previous notions about morphogens and axon guidance molecules, and suggest that these proteins, rather than ...
متن کاملPlexin A Is a Neuronal Semaphorin Receptor that Controls Axon Guidance
The Semaphorins comprise a large family of secreted and transmembrane proteins, some of which function as repellents during axon guidance. Semaphorins fall into seven subclasses. Neuropilins are neuronal receptors for class III Semaphorins. In the immune system, VESPR, a member of the Plexin family, is a receptor for a viral-encoded Semaphorin. Here, we identify two Drosophila Plexins, both of ...
متن کامل